Aluminium lithium hydride → HCID 178479442, compound

Participants

Reaction Conditions

Reaction Steps

4.2 g of lithium aluminum hydride were suspended in 150 ml of absolute tetrahydrofuran and cooled to 0° C. in an ice bath. 9.3 g of the methyl ester of tritylarginine hydrochloride, which were dissolved in 50 ml of absolute tetrahydrofuran, were slowly added dropwise to this suspension. The mixture was stirred at 0° C. for 30 min and then heated to 40°-45° C. After 30 min, the excess lithium aluminum hydride was decomposed with ice-water. Insolubles were removed by filtration, and the tetrahydrofuran was substantially removed by evaporation. The residue was neutralised with 0.1 N hydrochloric acid, taken up in n-butanol/ethyl acetate (1:1 parts by volume) and the solution was washed with water. After removal of the organic solvent by evaporation, tritylargininol hydrochloride was obtained in the form of a foam.

Provenance & Evidence