Potassium Carbonate → 4H-1,3,4-Oxadiazin-5(6H)-one, 2-(2,8-dimethylimidazo(1,2-a)pyridin-3-yl)-

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Reaction Steps

A mixture of 6 g of N'-chloroacetyl-2,8-dimethylimidazo[1,2-a]pyridine-3-carbohydrazide and 10 g of potassium carbonate in 50 ml of dimethylformamide is stirred under heating at 70°-90° C. for 1.5 hours. After the reaction mixture is allowed to cool, insoluble substances are collected by filtration, washed with water and recrystallized from a mixted solvent of chloroform and methanol to give 2.0 g of 2-(2,8-dimethylimidazo[1,2-a]pyridin-3-yl)-4,6-dihydro-1,3,4-oxadiazin-5-one as white crystals, melting at 310°-313° C. with decomposition.

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