Potassium Carbonate → HCID 14032916, compound

Participants

Reaction Steps

A mixture of 16 g of N'-chloroacetyl-6-methylimidazo[2,1-b]thiazole-5-carbohydrazide and 14 g of potassium carbonate in 160 ml of dimethylformamide is stirred under heating at 50°-60° C. for 4 hours. After insoluble substances are filtered off, the dimethylformamide is distilled off and to residual oil is added ethanol. The precipitated crystals are collected by filtration and recrystallized from methanol to give 5.2 g of 2-(6-methylimidazo[2,1-b]thiazol-5-yl)-4,6-dihydro-1,3,4-oxadiazin-5-one as pale yellow crystals, melting at 274°-275° C. with decomposition.

Provenance & Evidence