Sodium → HCID 14032918, compound

Participants

Reaction Steps

To a solution of 0.5 g of metallic sodium in 60 ml of ethanol is added 6 g of hydroxymethyl-(6-methylimidazo[2,1-b]thiazol-5-yl)ketone-N-methoxycarbonylhydrazone hydrochloride, and stirred at room temperature for 3 hours. Crystals are collected by filtration, washed with water and then recrystallized from 50 ml of a mixed solvent of chloroform and methanol to give 3.5 g of 5-(6-methylimidazo[2,1-b]thiazol-5-yl)-3,6-dihydro-1,3,4-oxadiazin-2-one as white crystals, melting at 294° C. with decomposition.

Provenance & Evidence