反应详情

To a mixture of 4 liters of acetone and 110 g (1.5 moles) of ammonium thiocyanate are added dropwise 173 g (1.23 moles) of benzoyl chloride. The reaction mixture is then heated for a further 15 minutes. Next, 200 g (1.23 moles) of 3,5-dichlorophenyl aniline dissolved in 200 ml of acetone are added. The mixture is then heated for a further 30 minutes, cooled and poured into 4 liters of water. The precipitate is collected and rinsed with 1 liter of water. The crystals are mixed with 2 liters of water containing 50 g of sodium hydroxide. The mixture is heated for 30 minutes and then cooled. The precipitate is collected to give 238 g (88%) of N-[3,5-dichlorophenyl]thiourea, m.p. 180° C.

1. temperatureThe reaction mixture is then heated for a further 15 minutes
2. additionare added
3. temperatureThe mixture is then heated for a further 30 minutes
4. temperaturecooled
5. customThe precipitate is collected
6. washrinsed with 1 liter of water
7. additionThe crystals are mixed with 2 liters of water containing 50 g of sodium hydroxide
8. temperatureThe mixture is heated for 30 minutes
9. temperaturecooled
10. customThe precipitate is collected