Methyl iodide → HCID 14031830, compound

Participants

Reaction Steps

A solution of 53 g of N-[3,5-dichlorophenyl]-N'-[2-methylpropyl]thiourea in 200 ml of acetone was heated under reflux. A total of 16 ml of methyl iodide was added dropwise, heating is continued for a further 3 hours after this addition. The reaction mixture was then cooled and the precipitate collected to give 50 g (55.5%) of N-[3,5-dichlorophenyl]-N'-[2-methylpropyl]-carbamimidothioic acid, methyl ester, hydroiodide, m.p. 150° C. Concentration of the mother liquors and recrystallization in ethanol/isopropyl ether afforded a further 20 g of the product. Total yield: 77%.

Provenance & Evidence