Hexane → HCID 13711423, compound

HRID 986410Notes

Reaction equation

HRID 986410 reaction equation
[Cl:1][C:2]1[C:8]([C:9]([F:12])([F:11])[F:10])=[CH:7][C:6]([Cl:13])=[CH:5][C:3]=1[NH2:4].[F:14][C:15]1[CH:25]=[CH:24][CH:23]=[C:22]([F:26])[C:16]=1[C:17]([N:19]=[C:20]=[O:21])=[O:18].CCCCCC>C1C=CC=CC=1>[Cl:1][C:2]1[C:8]([C:9]([F:11])([F:10])[F:12])=[CH:7][C:6]([Cl:13])=[CH:5][C:3]=1[NH:4][C:20]([NH:19][C:17](=[O:18])[C:16]1[C:22]([F:26])=[CH:23][CH:24]=[CH:25][C:15]=1[F:14])=[O:21]

Participants

5

Reactant 3

HCID 8058HexaneHCID 27333692,6-Difluorobenzoyl isocyanateHCID 136718552,5-Dichloro-3-(trifluoromethyl)aniline

Product 1

HCID 13711423HCID 13711423, compoundYield 83.5%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent2×

Procedure

To a solution of 2,5-dichloro-3-trifluoromethyl aniline (0.6 g) in 10 ml of dry benzene was added dropwise a solution of 2,6-difluorobenzoylisocyanate (0.5 g) in 5 ml of dry benzene under water-cooling and the solution was stirred for one hour at room temperature. 50 ml of n-hexane was added to the above solution and the precipitated crystal was filtered. The crystal was washed with n-hexane to obtain the desired product 0.9 g. (m.p. 205°-207.5° C.)

Workup

  1. temperaturecooling
  2. filtrationthe precipitated crystal was filtered
  3. washThe crystal was washed with n-hexane

Sources & evidence

ORD record
ord-b09826034f8c4546b102066675bfcde1
Source dataset
uspto-grants-1987_12
Patent number
US04713396

Reaction notes

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