2,6-Difluorobenzoylisothiocyanate → HCID 13711438, compound

HRID 986412Notes

Reaction equation

HRID 986412 reaction equation
[Cl:1][C:2]1[C:8]([C:9]([F:12])([F:11])[F:10])=[CH:7][C:6]([Cl:13])=[CH:5][C:3]=1[NH2:4].[F:14][C:15]1[CH:25]=[CH:24][CH:23]=[C:22]([F:26])[C:16]=1[C:17]([N:19]=[C:20]=[S:21])=[O:18]>C1C=CC=CC=1>[Cl:1][C:2]1[C:8]([C:9]([F:11])([F:10])[F:12])=[CH:7][C:6]([Cl:13])=[CH:5][C:3]=1[NH:4][C:20]([NH:19][C:17](=[O:18])[C:16]1[C:22]([F:26])=[CH:23][CH:24]=[CH:25][C:15]=1[F:14])=[S:21]

Participants

4

Reactant 2

HCID 109655092,6-DifluorobenzoylisothiocyanateHCID 136718552,5-Dichloro-3-(trifluoromethyl)aniline

Product 1

HCID 13711438HCID 13711438, compoundYield 64.3%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent2×

Procedure

To a solution of 2,5-dichloro-3-trifluoromethylaniline (0.5 g) in 10 ml of dry benzene was added a solution of 2,6-difluorobenzoylisothiocyanate (0.45 g) in 5 ml of dry benzene under water-cooling and the solution was stirred for 10 hours. The benzene was then distilled off under reduced pressure and the residue was washed with n-hexane to obtain the desired product 0.6 g. (m.p. 136°-141° C.)

Workup

  1. temperaturecooling
  2. distillationThe benzene was then distilled off under reduced pressure
  3. washthe residue was washed with n-hexane

Sources & evidence

ORD record
ord-d4116d54a0244a1fb940422481a6ef78
Source dataset
uspto-grants-1987_12
Patent number
US04713396

Reaction notes

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