P-Chloroacetophenone → HCID 3456926, compound

Participants

Reaction Steps

300 g (1.94 moles) of 4-chloroacetophenone are added dropwise to a suspension of 105 g (1.94 moles) of sodium methylate in 1.7 l of diethyl ether. 144 g (1.94 moles) of ethyl formate are added dropwise at room temperature, with cooling. The reaction mixture is stirred under reflux for 3 hours and cooled to room temperature and the precipitate is filtered off with suction. The precipitate is dissolved in water, the pH value is brought to 1-2 with dilute hydrochloric acid, the mixture is extracted with ethyl acetate and the organic phase is concentrated. 216 g (61% of theory) of 4-chlorophenyl hydroxyvinyl ketone of melting point 44° C. are obtained.

Provenance & Evidence