Sodium borohydride → HCID 11744819, compound

HRID 986468Notes

Reaction equation

HRID 986468 reaction equation
[BH4-].[Na+].[N:3]1[CH:8]=[C:7]([C:9]([CH:11]([CH3:13])[CH3:12])=[O:10])[CH:6]=[N:5][CH:4]=1>O.CO>[OH:10][CH:9]([C:7]1[CH:6]=[N:5][CH:4]=[N:3][CH:8]=1)[CH:11]([CH3:13])[CH3:12]

Participants

5

Reactant 2

HCID 4311764Sodium borohydrideHCID 13645651HCID 13645651, compound

Product 1

HCID 11744819HCID 11744819, compoundYield 99.3%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

1.27 g (0.034 mole) of sodium borohydride in 10 ml of water are added to 15 g (0.1 mole) of isopropyl 5-pyrimidinyl ketone in 100 ml of methanol at room temperature. The reaction mixture is subsequently stirred at room temperature for 1 hour and is concentrated in vacuo, the residue is taken up in methylene chloride and the mixture is concentrated again in vacuo. 15.1 g (99.3% of theory) of 5-(1-hydroxy-2-methyl-propyl)-pyrimidine of refractive index nD20 =1.5082 are obtained.

Workup

  1. concentrationis concentrated in vacuo
  2. concentrationthe mixture is concentrated again in vacuo

Sources & evidence

ORD record
ord-b398b935b6004be0a230876b85346953
Source dataset
uspto-grants-1987_12
Patent number
US04713456

Reaction notes

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