HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Alcohol → HCID 54453405, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Alcohol | HCID 244 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | Methyl (2-{[(benzyloxy)carbonyl]amino}-1,3-thiazol-4-yl)acetate | HCID 14121877 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 54453405 | HCID 54453405 | 45% |
Reaction Steps
A mixture of 3-methoxyacrylic acid methyl ester (1), benzyl alcohol (1.2 equivalents), a solution of sodium methoxide in methanol (0.05 equivalents), and toluene (3.7 parts) is heated for 3 hours to remove methanol under azeotropic distillation. The mixture is concentrated in vacuo to remove the solvent, distilled in vacuo to remove by-products (94° to 112° C. at 3 mmHg), and cooled. The residue is chromatographed over silica gel (benzene:ethyl acetate=95:5) to give 3-benzyloxyacrylic acid benzyl ester (2). Yield: 45%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04713461 |
| Source dataset | uspto-grants-1987_12 |
| ORD ID | ord-250a01967f824635a70b086f40012719 |
| Source note | uspto-grants-1987_12 |