HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiophenol → Ethyl Fluoro(phenylthio)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiophenol | HCID 7969 | — |
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Reactant | Acetic acid, 2-bromo-2-fluoro-, ethyl ester | HCID 2733407 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Ethyl Fluoro(phenylthio)acetate | HCID 11148583 | 90% |
Reaction Steps
To 150 ml of tetrahydrofuran (THF) were added 6.5 g (0.1 mole) of pulverized EtONa and 11.1 g (0.1 mole) of thiophenol and the mixture was refluxed for 10 minutes. Thereto was added 18.5 g (0.1 mole) of ethyl fluorobromoacetate and the mixture was refluxed for one hour with stirring. THF was removed by an evaporator and the precipitated NaBr was filtered. The organic layer was washed with water, dried and distilled to obtain 19.2 g (90%) of ethyl fluoro(phenylthio)acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04713469 |
| Source dataset | uspto-grants-1987_12 |
| ORD ID | ord-034b39cd848445a797046d51f9e66e48 |
| Source note | uspto-grants-1987_12 |