Dimethyl Carbonate → Methyl 4-(4-Benzyloxyphenoxy)-3-oxopentanoate

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

3-(4-Benzyloxyphenoxy)-2-butanone (5.0 g) was dissolved in 25 ml of dimethyl carbonate and added to a 50 ml, three-necked, round-bottom flask fitted with a thermometer, condenser, magnetic stirrer and nitrogen sweep. The solution was heated to 85° C. in an oil bath, then charged with 0.51 g of sodium over a period of 0.5 hour. The resulting clear yellow solution began off-passing after 15 minutes, and then turned a cloudy yellow. After 1 hour, the condenser was replaced with a Vigreux column and distillation head, and the bath temperature was raised to 130° C. Methanol was distilled off for 45 minutes. After approximately 4.5 hours, the reaction was stopped and the solution let cool to room temperature. The dimethyl carbonate was stripped off, and the residue rediluted with 50 ml of ethyl acetate. The solution was then washed with a solution of 50 ml of ice water and 5 ml of acetic acid and then with 50 ml of water. The organic phase was dried over magnesium sulfate, filtered, and stripped. The crude yield was 6.06 g of an orange oil. This was submitted for analysis and found to contain 82% of the desired product, methyl 4-(4-benzyloxyphenoxy)-3-oxopentanoate.

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