反应详情

A mixture of 3-(2-amino-3,5-dichlorophenyl)-5-phenyl-1H-1,2,4-triazole (6 g) and ethylcarbamate (50 g) is heated under nitrogen at 195° for 6 hours after which it is cooled to 80°, poured into water (1000 ml) and stirred 16 hours. The product is collected, washed with water, then methanol (300 ml) and air dried. The crude material is recrystallized from 12:1 2-methoxyethanol-water to afford pure 7,9-dichloro-2-phenyl-[1,2,4]triazolo[1,5-c]quinazolin-5(6H)one, mp 309°-311°.

1. temperatureis heated under nitrogen at 195° for 6 hours after which it
2. temperatureis cooled to 80°
3. customThe product is collected
4. washwashed with water
5. dry with materialmethanol (300 ml) and air dried
6. customThe crude material is recrystallized from 12:1 2-methoxyethanol-water