4-Hydroxybenzoic acid hydrazide → HCID 135736241, compound

Participants

Reaction Steps

The intermediate prepared from 2-isocyanato-5-chlorobenzonitrile (6.1 g) and 4-hydroxybenzoylhydrazine (7.0 g) in 53% yield as described in Example 23 is added to a mixture of triethylamine (31 ml), methanesulphonic acid (25 drops) and ethanol (300 ml) and stirred at reflux under nitrogen for two hours. The reaction mixture is concentrated to dryness at reduced pressure, redissolved in ethanol and treated with water. The solid is collected, washed with water and dried under high vacuum to afford pure 9-chloro-2-(4-hydroxy-phenyl)-[1,2,4]triazolo[1,5-c]quinazolin-5(6H)one, mp>350°

Provenance & Evidence