HCID 14031946, compound → HCID 14031905, compound

HRID 986507Notes

Reaction equation

HRID 986507 reaction equation
[Cl:1][C:2]1[CH:11]=[CH:10][C:9]2[N:8]=[C:7](SC)[N:6]3[N:14]=[C:15]([C:17]4[O:18][CH:19]=[CH:20][CH:21]=4)[N:16]=[C:5]3[C:4]=2[CH:3]=1>C1(N)CCCCC1>[Cl:1][C:2]1[CH:11]=[CH:10][C:9]2[N:8]=[C:7]([NH:8][CH:9]3[CH2:10][CH2:11][CH2:2][CH2:3][CH2:4]3)[N:6]3[N:14]=[C:15]([C:17]4[O:18][CH:19]=[CH:20][CH:21]=4)[N:16]=[C:5]3[C:4]=2[CH:3]=1

Participants

3

Reactant 1

HCID 14031946HCID 14031946, compound

Product 1

HCID 14031905HCID 14031905, compound

Reagents, catalysts & solvents 1

HCID 7965CyclohexylamineSolvent

Procedure

A mixture of 9-chloro-2-(2-furyl)-5-methylthio(1,2,4]triazolo[1,5-c]quinazoline (5.7 g) is refluxed with cyclohexylamine (40 ml) under nitrogen for 6 hours. The mixture is cooled and the insoluble solid collected and recrystallized from ethanol to afford pure 9-chloro-5-cyclohexylamino-2-(2-furyl)-[1,2,4]triazolo[1,5-c]quinazoline, mp 158°-160°.

Workup

  1. temperatureThe mixture is cooled
  2. customthe insoluble solid collected
  3. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-be45dec8fc674df1a1edff7c98ec3c3a
Source dataset
uspto-grants-1987_12
Patent number
US04713383

Reaction notes

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