Methylamine → HCID 14086198, compound

Participants

Reaction Steps

To a solution of 1.45 g of 5,9-dichloro-2(2-furyl)[1,2,4]triazolo[1,5-c]quinazoline in dry tetrahydrofuran (150 cc) at 50° is added gaseous methylamine over 40 minutes. The mixture is concentrated to dryness, triturated with water and filtered to afford a white solid. This is recrystallized by dissolution in hot toluene and, after several minutes of heating to remove water by azeotropic distillation, addition of cyclohexane during cooling. Pure 9-Chloro-2-(2-furyl)-5-methylamino[1,2,4]triazolo[1,5-c]quinazoline, mp 166°-168°, is thus obtained.

Provenance & Evidence