HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Karetazan
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methyl 1-ethyl-6-methyl-2-(4'-chlorophenyl)-4-oxonicotinate | HCID 14075279 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | Karetazan | HCID 157722 | 95.5% |
Reaction Steps
46.1 g of crude methyl 1-ethyl-6-methyl-2-(4'-chlorophenyl)-4-oxonicotinate is suspended in 600 ml of 5% aqueous NaOH solution and warmed to 80°-85°. After 1-11/2 hours at this temperature the reaction mixture is cooled and acidified with dilute HCl. The resulting solid precipitate is collected by filtration, yielding 42 g of 1-ethyl-6-methyl-2-(4'-chlorophenyl)-4-oxonicotinic acid, mp (methylene chloride/ether)=235°-237° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04714492 |
| Source dataset | uspto-grants-1987_12 |
| ORD ID | ord-c6312fee139a49598e472b9375cf9c5c |
| Source note | uspto-grants-1987_12 |