HCID 13454826, compound → HCID 13454828, compound

HRID 986616Notes

Reaction equation

HRID 986616 reaction equation
[CH:1]([NH:4][C:5](=[O:19])[C@@H:6]([CH3:18])[NH:7]C(OCC1C=CC=CC=1)=O)([CH3:3])[CH3:2].[H][H]>CO.[Pd]>[CH:1]([NH:4][C:5](=[O:19])[C@@H:6]([CH3:18])[NH2:7])([CH3:3])[CH3:2]

Participants

5

Reactant 2

HCID 13454826HCID 13454826, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 13454828HCID 13454828, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

N-Benzyloxycarbonyl-D-alanine isopropyl amide (1.322 g, 5 mmol) is hydrogenated in 20 mL MeOH over 100 mg 10% Pd/C in a Parr Apparatus at 40 psi and room temperature until no more hydrogen is consumed. The methanolic suspension is filtered through a Celite pad to remove the catalyst and the filtrate is evaporated to dryness. The desired product is purified by conversion into a crystalline amino acid amide salt.

Workup

  1. customis consumed
  2. filtrationThe methanolic suspension is filtered through a Celite pad
  3. customto remove the catalyst
  4. customthe filtrate is evaporated to dryness
  5. customThe desired product is purified by conversion into a crystalline amino acid amide salt

Sources & evidence

ORD record
ord-d52bc086a3724fbc9c3e5924cd756e61
Source dataset
uspto-grants-1987_12
Patent number
US04714619

Reaction notes

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