HCID 178418361, compound → HCID 178486675, compound

Participants

Reaction Steps

A slurry of 2.028 grams 3-hydroxy-6,7-dimethoxy-1-methyl-4-nitroisoquinoline (BA) (7.67 mmol) in 28 ml acetic anhydride and 180 ml acetic acid was hydrogenated using 0.8 grams of a 10% palladium on carbon catalyst at 25 psi hydrogen pressure in a Parr hydrogenator for 3 hours. The mixture was filtered through a Celite pad, and the collected solids were washed with acetic acid. The filtrate and the wash liquids were combined and evaporated to dryness. The residue was recrystallized from methanol to provide 0.70 grams of Compound BG (33% yield) having a melting point of >300° C. (with decomposition).

Provenance & Evidence