Fluoroacetyl chloride → HCID 13376457, compound

HRID 986652Notes

Reaction equation

[NH2:1][C:2]1[CH:18]=[CH:17][C:16]([N+:19]([O-:21])=[O:20])=[CH:15][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([CH3:13])[C:8]=1[CH3:14])=[O:5].[F:22][CH2:23][C:24](Cl)=[O:25]>>[F:22][CH2:23][C:24]([NH:1][C:2]1[CH:18]=[CH:17][C:16]([N+:19]([O-:21])=[O:20])=[CH:15][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([CH3:13])[C:8]=1[CH3:14])=[O:5])=[O:25]

Participants

Reactant 2

HCID 9663Fluoroacetyl chloride

HCID 13376449HCID 13376449, compound

Product 1

HCID 13376457HCID 13376457, compoundYield 87.2%

Procedure

3.6 g of N-(2-amino-5-nitrobenzoyl)-2,3-dimethylaniline and 1.82 g of fluoroacetyl chloride are treated in the same manner as described in Example 1-(1), whereby 3.8 g of N-(2-fluoroacetamido-5-nitrobenzoyl)-2,3-dimethylaniline are obtained as colorless needles.

Sources & evidence

ORD record: ord-2793a712614c48d49e3848eb9da2a651
Source dataset: uspto-grants-1987_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04714702

Reaction notes

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