Fluoroacetyl chloride → HCID 13376460, compound

HRID 986660Notes

Reaction equation

HRID 986660 reaction equation
[NH2:1][C:2]1[CH:18]=[CH:17][C:16]([N+:19]([O-:21])=[O:20])=[CH:15][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:8]=1[CH3:14])=[O:5].[F:22][CH2:23][C:24](Cl)=[O:25]>N1C=CC=CC=1>[F:22][CH2:23][C:24]([NH:1][C:2]1[CH:18]=[CH:17][C:16]([N+:19]([O-:21])=[O:20])=[CH:15][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:8]=1[CH3:14])=[O:5])=[O:25]

Participants

4

Reactant 2

HCID 9663Fluoroacetyl chlorideHCID 13376453HCID 13376453, compound

Product 1

HCID 13376460HCID 13376460, compoundYield 95.7%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

4.5 g of N-(2-amino-5-nitrobenzoyl)-2-methyl-5-fluoroaniline, 1.85 g of pyridine and 2.26 g of fluoroacetyl chloride are treated in the same manner as described in Example 1-(1), whereby 5.2 g of N-(2-fluroacetamido-5-nitrobenzoyl)-2-methyl-5-fluoroaniline are obtained as colorless needles.

Sources & evidence

ORD record
ord-ecf4ad38ffaa41cca03e383db09ff6ed
Source dataset
uspto-grants-1987_12
Patent number
US04714702

Reaction notes

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