Fluoroacetyl chloride → HCID 13376461, compound

HRID 986661Notes

Reaction equation

HRID 986661 reaction equation
[NH2:1][C:2]1[CH:18]=[CH:17][C:16]([N+:19]([O-:21])=[O:20])=[CH:15][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[C:11]([Cl:13])[CH:10]=[CH:9][C:8]=1[CH3:14])=[O:5].[F:22][CH2:23][C:24](Cl)=[O:25]>N1C=CC=CC=1>[F:22][CH2:23][C:24]([NH:1][C:2]1[CH:18]=[CH:17][C:16]([N+:19]([O-:21])=[O:20])=[CH:15][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[C:11]([Cl:13])[CH:10]=[CH:9][C:8]=1[CH3:14])=[O:5])=[O:25]

Participants

4

Reactant 2

HCID 9663Fluoroacetyl chlorideHCID 13376454HCID 13376454, compound

Product 1

HCID 13376461HCID 13376461, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

4.0 g of N-(2-amino-5-nitrobenzoyl)-2-methyl-5-chloroaniline, 1.54 g of pyridine and 1.88 g of fluoroacetyl chloride are treated in the same manner as described in Example 1-(1), whereby 4.5 g of N-(2-fluoroacetamido-5-nitrobenzoyl)-2-methyl-5-chloroaniline are obtained as pale yellow needles.

Sources & evidence

ORD record
ord-6ca036b714244acca6bb090ae5982018
Source dataset
uspto-grants-1987_12
Patent number
US04714702

Reaction notes

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