4-Aminopyridine → HCID 70381943, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 1.665 g (10 m mol) of 2- chloromethybenzimidazole and 1.88 g (20 m mol) of 4- aminopyridine in 20 ml of ethanol was refluxed under heating for three hours. The solution was evaporated in vacuo to a dark oil, dissolved in 20 ml of water and washed twice with 20 ml of ethylacetate The aqueous phase was evaporated in vacuo. The residual oil was dissolved in 3 ml of concentrated hydrochloric acid and chilled (0° C.) causing a crystalline precipitate to form. The crystals were filtered with the aid of ethanol. Recrystallization from methanol gave 1.68 g (53.3%) of the title compound (I).

Provenance & Evidence