Chloroacetic Acid → HCID 178423949, compound

Participants

Reaction Steps

A solution of 1.83 g (15 m mol) of 3-methyl-1,2-phenylenediamine in 20 ml of 4N aqueous hydrochloric acid was stored at room temperature overnight. To the solution was added 2.13 g (22.5 m mol) of monochloroacetic acid and refluxed for 3 hours. The reaction solution was cooled to room temperature, rendered alkaline by addition of ammonium hydroxide and extracted with ethyl acetate. The ethyl acetate layer was washed with water and dried on anhydrous sodium sulfate. The solvent was evaporated in vacuo and the residue was crystallized from ethyl ether to give 0.8 g (29.52%).

Provenance & Evidence