Chlorzoxazone → 2,5-Dichlorobenzooxazole

HRID 986673Notes

Reaction equation

HRID 986673 reaction equation
[Cl:1]C1C=CC2NC(=O)OC=2C=1.[Cl:12][C:13]1[CH:14]=[CH:15][C:16]2[O:20][C:19](=O)[NH:18][C:17]=2[CH:22]=1>>[Cl:1][C:19]1[O:20][C:16]2[CH:15]=[CH:14][C:13]([Cl:12])=[CH:22][C:17]=2[N:18]=1

Participants

3

Reactant 2

HCID 2733ChlorzoxazoneHCID 298586-Chloro-2,3-dihydrobenzoxazol-2-one

Product 1

HCID 103975782,5-Dichlorobenzooxazole

Procedure

If the process is carried out as in Example 1, but, instead of 6-chlorobenzoxazolin-2-one, the same amount of 5-chlorobenzoxazolin-2-one is used, then about 130 g, corresponding to 69% of theory, of 2,5-dichlorobenzoxazole, melting point 46°-48° C., are obtained.

Sources & evidence

ORD record
ord-541b185671644fc7a9e440001655fe13
Source dataset
uspto-grants-1987_12
Patent number
US04714766

Reaction notes

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