Thionyl Chloride → 2-[(4-Dodecyloxyphenyl)sulfonyl]butanoyl Chloride

Participants

Reaction Conditions

Reaction Steps

2-[(4-Dodecyloxyphenyl)sulfonyl]butanoic acid (19.5 g, 47.33 mMole) was suspended in ethyl acetate (150 mL) to which was added several drops of dimethylformamide and thionyl chloride (14.4 mL, 119 mMole). The mixture was heated at 70° C. for 1.5 hours, cooled, concentrated under reduced pressure, co-evaporated with ethyl acetate (2×100 mL) and the oil so obtained used as such in the next step of the reaction sequence.

Provenance & Evidence