Dichloromethane → HCID 13745628, compound

Participants

Reaction Steps

A mixture of 4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]-3-fluorobenzoic acid (700 mg), dichloromethane (25 ml), triethylamine (2ml), acetic anhydride (2ml) and 4-dimethylaminopyridine (catalytic amount) was stirred at ice-cooling to room temperature for 6.5 hours. To the reaction mixture was added methanol (2ml), and the mixture was stirred for 30 minutes. After concentration, water was added to the residue. Solid materials were recovered by filtration and subjected to recrystallization from aqueous methanol to give crystals of 4-[3-(3-acetoxy-4-acetyl-2-propylphenoxy)propoxy]-3-fluorobenzoic acid (723 mg). m.p. 144°-145° C.

Provenance & Evidence