Dimethylamine → Pyridazino(4,3-c)isoquinolin-6-amine, N,N-dimethyl-3-phenyl-

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Reaction Steps

Dimethylamine (6 g), 6-chloro-3-phenyl-pyridazino-[4,3-c]isoquinoline (5.83 g, 0.02 mol) and dimetoxyethane (120 ml) are heated at 120° C. for about 8 hours in a bomb. Then the reaction mixture is concentrated to dryness under reduced pressure, the residue is disaggregated with water (200 ml) and the solid recovered by filtration is dried, yielding 5.8 g of a crude product which is crystallized from acetone to give 3.2 g of the product of the title. M.p. 134°-136° C. A further crop of about 1,7 g is obtained by purifying the residue of the concentration of the mothers liquors by means of a silica gel column chromatography which uses chloroform as the eluent. Overall yield 4,9 g (81,5%).

Provenance & Evidence