Acetic Acid → HCID 13851038, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 6-(1-bromo-1-methylethyl)-4-oxo-4H-1-benzopyran-3-carbonitrile (2.0 g), acetic acid (20 ml) and water (5 ml) was heated at 100° C. for one hour, which was then concentrated. The concentrate was subjected to a silica-gel (100 g) column-chromatography, eluting with chloroform-acetone-formic acid (20:1:0.1). The initial eluate was recrystallized from ethanol to give colorless crystals (600 mg) of 6-isopropenyl-4-oxo-4H-1-benzopyran-3-carbonitrile, m.p. 142°-144° C.

Provenance & Evidence