Sodium Acetate → HCID 13851038, compound

Participants

Reaction Steps

A mixture of 6-(1-bromo-1-methylethyl)-4-oxo-4H-1-benzopyran-3-carbonitrile (2.0 g), sodium acetate (575 mg) and dimethylformamide (20 ml) was heated for one hour, which was then concentrated. The concentrate was dissolved in chloroform. The solution was washed with water and dried (sodium sulfate), followed by removing chloroform by evaporation. The residue was subjected to a silica-gel (100 g) column chromatography, eluting with chloroform-acetone-formic acid (20:1:0.1). The initial eluate was recrystallized from ethanol to give colorless crystals (1.07 g) of 6-isopropenyl-4-oxo-4H-1-benzopyran-3-carbonitrile, m.p. 142°-144° C.

Provenance & Evidence