Sodium Hydroxide → HCID 20156362, compound

Participants

Reaction Conditions

Reaction Steps

A suspension consisting of ethyl 2-amino-7-(1-hydroxy-1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]-pyridine-3-carboxylate (37.3 g), ethanol (2.3 l) and 0.5N sodium hydroxide (620 ml) was stirred at 50° C. for 2 hours, then ethancl was evaporated off. The concentrate was acidified with hydrochloric acid (pH 3-4), then the resulting precipitates were collected by filtration and washed with water, followed by recrystallization from dimethylformamide-water. The crystals were washed with ethanol to give 2-amino-7-(1-hydroxy-1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]-pyridine-3-carboxylic acid (32.5 g).

Provenance & Evidence