Ethanol → HCID 13851042, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of ethyl 2-amino-7-(2-hydroxy-1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylate (480 mg), ethanol (40 ml), water (5 ml) and 1N sodium hydroxide (5 ml) was heated at 50° C. for 80 minutes, which was then concentrated. The concentrate was dissolved in water, which was made acid with 10% hydrochloric acid. Resulting precipitates were collected by filtration, washed with water, and recrystallized from dimethylformamide-ethanol-water to yield colorless crystals (386 mg) of 2-amino-7-(2-hydroxy-1-methylethyl)-5-oxo-5H-[1]benzopyrano-[2,3-b]pyridine-3-carboxylic acid, m.p. >300° C.

Provenance & Evidence