Dimethylamine → HCID 13670626, compound

HRID 986766Notes

Reaction equation

HRID 986766 reaction equation
Cl[S:2]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[N:12]=[C:13]3[N:18]=[CH:17][CH:16]=[CH:15][N:14]3[CH:19]=2)=[CH:7][CH:6]=1)(=[O:4])=[O:3].[CH3:20][NH:21][CH3:22]>O>[CH3:20][N:21]([CH3:22])[S:2]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[N:12]=[C:13]3[N:18]=[CH:17][CH:16]=[CH:15][N:14]3[CH:19]=2)=[CH:7][CH:6]=1)(=[O:4])=[O:3]

Participants

4

Reactant 2

HCID 674DimethylamineHCID 20156433HCID 20156433, compound

Product 1

HCID 13670626HCID 13670626, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Conditions

Temperature
50 °C

Procedure

2.9 g (0.01 mol) of 2-(4-Chlorosulphonyl-phenyl)-imidazo[1,2-a]pyrimidine are suspended in 60 ml of a 40% solution of dimethylamine in water. The mixture is heated to 50° C. for 30 minutes, diluted with 50 ml of water, extracted with ethyl acetate, then the ethyl acetate extract is dried and evaporated to dryness. The residue is recrystallised from dimethylformamide.

Workup

  1. extractionextracted with ethyl acetate
  2. extractionthe ethyl acetate extract
  3. customis dried
  4. customevaporated to dryness
  5. customThe residue is recrystallised from dimethylformamide

Sources & evidence

ORD record
ord-5bb0c2d4c87d40f28ad2f635f683bf6d
Source dataset
uspto-grants-1987_12
Patent number
US04716169

Reaction notes

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