HRID986782

反应详情

EQUATION

反应方程式

REACTANTS

反应物

反应SMILES：CCON=C(C(=O)O)c1csc(NC(=O)CCl)n1

HCID54083585

未命名化合物

反应SMILES：COCC1=C(C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)C(N)[C@H]2SC1

HCID70432979

未命名化合物

PRODUCTS

产物

反应SMILES：CCON=C(C(=O)NC1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(COC)CS[C@H]12)c1csc(NC(=O)CCl)n1

HCID131713974

未命名化合物

收率 84%

PROCEDURE

实验过程

Following the method of Preparation 3, 225 mg of 2-(2-chloroacetamidothiazol-4-yl)-2-ethoxyiminoacetic acid and 200 mg of benzhydryl 7-amino-3-methoxymethyl-3-cephem-4-carboxylate were reacted to give 280 mg of benzhydryl 7-[2-(2-chloroacetamidothiazol-4-yl)-2-ethoxyiminoacetamido]-3-methoxymethyl-3-cephem-4-carboxylate, in the form of a yellow powder.

WORKUP

后处理

customwere reacted

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-bc48049d3a174a72824ef36d339a967b
来源数据集: uspto-grants-1987_12
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US04716158
来源说明: uspto-grants-1987_12

反应SMILES

[Cl:1][CH2:2][C:3]([NH:5][C:6]1[S:7][CH:8]=[C:9]([C:11](=[N:15][O:16][CH2:17][CH3:18])[C:12]([OH:14])=O)[N:10]=1)=[O:4].[NH2:19][CH:20]1[C:46](=[O:47])[N:22]2[C:23]([C:30]([O:32][CH:33]([C:40]3[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=3)[C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)=[O:31])=[C:24]([CH2:27][O:28][CH3:29])[CH2:25][S:26][C@H:21]12>>[Cl:1][CH2:2][C:3]([NH:5][C:6]1[S:7][CH:8]=[C:9]([C:11](=[N:15][O:16][CH2:17][CH3:18])[C:12]([NH:19][CH:20]2[C:46](=[O:47])[N:22]3[C:23]([C:30]([O:32][CH:33]([C:40]4[CH:41]=[CH:42][CH:43]=[CH:44][CH:45]=4)[C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=4)=[O:31])=[C:24]([CH2:27][O:28][CH3:29])[CH2:25][S:26][C@H:21]23)=[O:14])[N:10]=1)=[O:4]