Thiourea → HCID 131713975, compound

Participants

Reaction Steps

191 mg of this benzhydryl 7-[2-(2-chloroacetamidothiazol-4-yl)-2-ethoxyiminoacetamido]-3-methoxymethyl-3-cephem-4-carboxylate were then treated with 40 mg of thiourea, as described in Preparation 4, to give 117 mg of benzhydryl 7-[2-(2-aminothiazol-4-yl)-2-ethoxyiminoacetamido]-3-methoxymethyl-3-cephem-4-carboxylate, in the form of a pale pink powder, which was then treated with 1.5 ml of trifluoroacetic acid in a mixture of anisole and methylene chloride. When diisopropyl ether was added to the mixture, a precipitate was obtained and this was collected by filtration, to give 90 mg of 7-[2-(2-aminothiazol-4-yl)-2-ethoxyiminoacetamido]-3-methoxymethyl-3-cephem-4-carboxylic acid trifluoroacetate.

Provenance & Evidence