(2-Formamido-1,3-thiazol-4-yl)(oxo)acetic acid → HCID 131713977, compound

HRID 986786Notes

Reaction equation

HRID 986786 reaction equation
C1(C)C=CC(S(O)(=O)=O)=CC=1.[NH2:12][CH:13]1[C:34](=[O:35])[N:15]2[C:16]([C:23]([O:25][CH:26]([O:28][C:29]([O:31][CH2:32][CH3:33])=[O:30])[CH3:27])=[O:24])=[C:17]([CH2:20][O:21][CH3:22])[CH2:18][S:19][C@H:14]12.[CH:36]([NH:38][C:39]1[S:40][CH:41]=[C:42]([C:44](=[O:48])[C:45](O)=[O:46])[N:43]=1)=[O:37]>>[CH:36]([NH:38][C:39]1[S:40][CH:41]=[C:42]([C:44](=[O:48])[C:45]([NH:12][CH:13]2[C:34](=[O:35])[N:15]3[C:16]([C:23]([O:25][CH:26]([O:28][C:29]([O:31][CH2:32][CH3:33])=[O:30])[CH3:27])=[O:24])=[C:17]([CH2:20][O:21][CH3:22])[CH2:18][S:19][C@H:14]23)=[O:46])[N:43]=1)=[O:37]

Participants

3

Reactant 2

HCID 13116693(2-Formamido-1,3-thiazol-4-yl)(oxo)acetic acidHCID 131713978HCID 131713978, compound

Product 1

HCID 131713977HCID 131713977, compoundYield 52.6%

Procedure

The procedure described in Preparation 21 was repeated, but using 2.8 g of 1-ethoxycarbonyloxyethyl 7-amino-3-methoxymethyl-3-cephem-4-carboxylate p-toluenesulphonate and 1.25 g of 2-(2-formamidothiazol-4-yl)glyoxylic acid, to give 1.5 g of the title compound.

Workup

  1. customThe procedure described in Preparation 21

Sources & evidence

ORD record
ord-7a675df30a27419a8d979be3b956e7e6
Source dataset
uspto-grants-1987_12
Patent number
US04716158

Reaction notes

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