Ethyl benzoylacetate → HCID 20156557, compound

Participants

Reaction Steps

A sample of 120 g (0.62 mole) of ethyl benzoylacetate was added to 1.44 g (0.062 mole) of sodium and 32.8 g (0.31 mole) of 2-vinylpyridine added under an atmosphere of nitrogen. The mixture was heated with mechanical stirring on the steam bath for 17 h. After cooling the reaction mixture to room temperature, 100 mL of 3N hydrochloric acid was added, and the aqueous mixture washed with ether. The hydrochloric acid layer was made basic with 10% potassium carbonate solution, and extracted with ether. The ether layer was washed with brine, dried (MgSO4), and the ether evaporated in vacuo to give 83.4 g (90% yield) of the crude title compound as a red oil.

Provenance & Evidence