Diethyl Ether → HCID 65661124, compound

Participants

Reaction Conditions

Reaction Steps

0.01 mol of L-alanine were dissolved in 20 ml of 1-molar sodium hydroxide solution, a solution of 0.01 mol of p-toluenesulfonyl chloride in 10 ml of diethyl ether was added, and the mixture was vigorously stirred for 4 h. The ether phase was separated off, and the aqueous phase was acidified to pH 3 with concentrated hydrochloric acid. The crude n-toluenesulfonyl-1-alanine started to crystallize (cooling to 4° C. where necessary) and was filtered off and recrystallized from 60% by volume aqueous alcohol. Melting point 130°-131° C.

Provenance & Evidence