HCID 615240, compound → 1H-Benzimidazol-5-amine,2-(2-furanyl)-(9CI)

HRID 986816Notes

Reaction equation

HRID 986816 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[NH:7][C:8]2[CH:14]=[C:13]([N+:15]([O-])=O)[CH:12]=[CH:11][C:9]=2[N:10]=1.[H][H]>C(O)C.[Pd]>[NH2:15][C:13]1[CH:12]=[CH:11][C:9]2[N:10]=[C:6]([C:2]3[O:1][CH:5]=[CH:4][CH:3]=3)[NH:7][C:8]=2[CH:14]=1

Participants

5

Reactant 2

HCID 615240HCID 615240, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 7442251H-Benzimidazol-5-amine,2-(2-furanyl)-(9CI)

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 2-(2-furyl)-5-nitrobenzimidazole (52 g, 0.2 mole) in 1 liter of absolute ethyl alcohol is reduced (Parr apparatus) using 5 percent palladium on carbon (50 percent wet) catalyst. An uptake of 44 lbs. (100 percent of theory) of hydrogen in one-half hr is noted. After the reduction is complete the catalyst is removed by filtration. The filtrate is used in part D.

Workup

  1. customis removed by filtration

Sources & evidence

ORD record
ord-aa099f7f0518468a87fc231b0a012561
Source dataset
uspto-grants-1987_12
Patent number
US04716168

Reaction notes

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