Ammonium Hydroxide → HCID 178426076, compound

Participants

Reaction Steps

To a mixture of 31 g. (0.146 m.) of 2,7-dimethyl-1H-imidazo[4,5-f]quinoline-9-ol and 1336 ml. (223 g. 1455 m.) of POCl3 is added dropwise 267.2 ml. of dimethylformamide. The mixture is stirred overnight at room temperature, then poured into 1000 ml. of ice. The solution is basified to pH 8.0 using conc. NH4OH, keeping the temperature below 20° C. It is then filtered, washed with H2O and air-dried. The crude product is recrystallized from 2000 ml. of MeOH, and concentrated in vacuo to yield 338 g. m.p. 314°-330° C.

Provenance & Evidence