HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → 2-Methoxybenzoylacetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Sodium amide | HCID 24533 | — |
| Reactant | Methyl 2-Methoxybenzoate | HCID 61151 | — |
| Product | 2-Methoxybenzoylacetonitrile | HCID 4962750 | 84% |
Reaction Steps
In agreement with this data the condensation of 2-methoxybenzoic acid methyl ester with acetonitrile using sodamide/liquid ammonia gives 2-methoxybenzoylacetonitrile in 84% yield, in contrast this same reaction using sodium hydride in benzene only leads to a 27.4% reaction yield. (Kawase, Bull, Chem. Soc. Japan, Vol. 35 (1962), pages 1869-1871.)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04716237 |
| Source dataset | uspto-grants-1987_12 |
| ORD ID | ord-5b875bdeebb3472cbd0b841bc53a3f2e |
| Source note | uspto-grants-1987_12 |