HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → 2-Thenoylacetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Ethyl 2-thenoate | HCID 76052 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-Thenoylacetonitrile | HCID 141853 | 92.6% |
Reaction Steps
78.1 grams (0.5 mole) of thiophene-2-carboxylic acid ethyl ester and 30 grams (1 mole) of sodium hydride (80% in suspension in white oil) were reacted with 41.5 grams (1 mole) of acetonitrile in 500 ml of dry toluene. There were obtained 70.0 grams (92.6% of theory) of 2-thiophenoylacetonitrile having a melting point of 110° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04716237 |
| Source dataset | uspto-grants-1987_12 |
| ORD ID | ord-88d47e30d4e14b23b6921d740fb6f67b |
| Source note | uspto-grants-1987_12 |