HCID 20156671, compound → HCID 20156658, compound

HRID 986851Notes

Reaction equation

HRID 986851 reaction equation
[NH2:1][CH:2]([CH2:4][CH2:5][CH2:6][C:7]([C:10]1[CH:15]=[C:14]([CH3:16])[C:13]([NH2:17])=[C:12]([CH3:18])[CH:11]=1)([CH3:9])[CH3:8])[CH3:3].[H][H]>C(O)(C)(C)C>[NH2:1][CH:2]([CH2:4][CH2:5][CH2:6][C:7]([CH:10]1[CH2:15][CH:14]([CH3:16])[CH:13]([NH2:17])[CH:12]([CH3:18])[CH2:11]1)([CH3:9])[CH3:8])[CH3:3]

Participants

4

Reactant 2

HCID 20156671HCID 20156671, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 20156658HCID 20156658, compound

Reagents, catalysts & solvents 1

HCID 6386tert-ButanolSolvent

Procedure

58 Parts of 2-amino-6-(4-amino-3,5-dimethylphenyl)-6-methylheptane, 640 parts of tert-butanol, and 12 parts of 5% Rh/Al2O2 were heated in an autoclave at 150°-60° C. with hydrogen at a pressure of 200 bar. After 15 hours hydrogen uptake was complete and the reaction mixture was then filtered free of catalyst. Distillation of the filtrate after removal of the tert-butanol gave 47 parts of 2-amino-6-(4-amino-3,5-dimethylcyclohexyl)-6-methylheptane b0.2 116°-8° C.

Workup

  1. filtrationthe reaction mixture was then filtered free of catalyst
  2. distillationDistillation of the filtrate
  3. customafter removal of the tert-butanol

Sources & evidence

ORD record
ord-a71084c8baef428cb9d390518e04b361
Source dataset
uspto-grants-1987_12
Patent number
US04716248

Reaction notes

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