Hydrochloric Acid → HCID 21363107, compound

Participants

Reaction Steps

0.40 g (1 mmol) of Nα-(4-nitrophenyl)-Nε-(benzyloxycarbonyl)-L-lysine is dissolved in 20 ml of ethanol, 5 ml of water and 0.5 ml (3.5 eq) of 5N hydrochloric acid in a 250 ml glass reactor (Paar apparatus). 0.5 g of palladium-on-charcoal (50% moisture and 10% active) is then introduced. The mixture is hydrogenated under a pressure of approximately 2.76×105 Pa for 45 minutes and at a temperature of 12° C. After filtration through celite, the filtrate is evaporated. The purplish oily residue is taken up in ethanol and precipitated from a large volume of acetone with stirring. After filtration, 0.3 g of a white crystalline powder is obtained, i.e. a final yield of 93%.

Provenance & Evidence