Hydrochloric Acid → HCID 70005344, compound

Participants

Reaction Steps

2 g (7.9 mmol) of 6-[N-(4-nitrophenyl)amino]caproic acid are partially dissolved in 40 ml of ethanol and 2 ml of water in a 150 ml three-necked flask equipped with a thermometer and a reflux condenser. 2 g of palladium-on-charcoal (10% active and 50% moisture) are then introduced, followed by 20 ml of cyclohexene. The mixture is brought to reflux for 2 hours and is then cooled, before being filtered through celite. After having run 4 ml (2.5 eq) of 5N hydrochloric acid onto the filtrate, the latter is evaporated to dryness and the residue is taken up in ethanol and precipitated from acetone. After filtration, 1.9 g of a white product are obtained, i.e. a final yield of 81%.

Provenance & Evidence