Ammonium Hydroxide → HCID 178461972, compound

Participants

Reaction Steps

To a solution of 4,6-Dichloro-N2-[(1S)-1-phenylethyl]-1,3,5-triazine-2-amine, (Compound of Example 14), in THF (500 mL) was added conc. NH4OH (50 mL). The reaction mixture was stirred at ambient temperature for 48 h then was concentrated under reduced pressure. The residue was dissolved in CH2Cl2 (500 mL) and was washed with H2O (2×250 mL). The organic layer was filtered through a cotton plug then dried over sodium sulfate, filtered and concentrated under reduced pressure to afford 4-Chloro-N2-[(1S)-1-phenylethyl]-1,3,5-triazine-2,4-diamine as a white solid (29.7 g, 90%) MP 163-164° C., 1H (CDCl3) δ 7.78 (m, 5H), 6.1-6.2 (m, 4H), 1.52 (d, 3H), MS (ESI+) (M+) 249.7 obs.

Provenance & Evidence