Bis(2-Methoxyethyl)amine → HCID 178495930, compound

Participants

Reaction Steps

Part F: 4-[Bis[2-methoxyethyl)amino]-7-(2,4-dichlorophenyl)-2,5-dimethyl-pyrrolo[3,4-d]pyrimidine hydrochloride salt: The compound of part E of Example 2 (0.1 g, 0.306 mmol) in dichloromethane (10.0 mL) was treated with bis (2-methoxyethyl)amine (123 mg, 0.92 mmol, 3 eq.) and refluxed for 3 days. The reaction mixture was concentrated in vacuum and recrystallized the solid to afford desired product as a yellow solid (HCl salt, 67 mg, mp 235-236° C., 48% yield). Anal. calcd. for C20H25Cl3N4O2: C, 52.08; H, 5.46; N, 11.85. Found: C, 52.24; H, 5.48; N, 12.18.

Provenance & Evidence