Phosphorus oxychloride → HCID 69288439, compound

Participants

Reaction Steps

8.0 g of (−)-cis-N-[2-(3,4-dimethoxyphenyl)cyclohexyl]-4-methanesulfonylbenzamide are suspended in 150 ml of toluene, treated with 4 ml of phosphorus oxychloride and heated under reflux for 5.5 h. The reaction solution is concentrated under reduced pressure, the residue is taken up in ethyl acetate and the mixture is extracted with satd sodium hydrogencarbonate solution and water. After chromatography on silica gel using petroleum etherlethyl acetate/triethylamine in the ratio 6/3/1, the title compound is obtained.

Provenance & Evidence