Ether hydrochloride → HCID 22987972, compound

HRID 986971Notes

Reaction equation

HRID 986971 reaction equation
FC(F)(F)C(O)=O.[F:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[C:23]3[C:18](=[N:19][CH:20]=[CH:21][N:22]=3)[NH:17][C:16]=2[C:24]2[CH:29]=[CH:28][N:27]=[C:26]([NH:30][CH2:31][CH2:32][CH2:33][OH:34])[CH:25]=2)=[CH:11][CH:10]=1.[ClH:35].C(OCC)C>>[ClH:35].[F:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[C:23]3[C:18](=[N:19][CH:20]=[CH:21][N:22]=3)[NH:17][C:16]=2[C:24]2[CH:29]=[CH:28][N:27]=[C:26]([NH:30][CH2:31][CH2:32][CH2:33][OH:34])[CH:25]=2)=[CH:11][CH:10]=1

Participants

3

Reactant 2

HCID 10953452Ether hydrochlorideHCID 17920696HCID 17920696, compound

Product 1

HCID 22987972HCID 22987972, compound

Procedure

7-(4-Fluorophenyl)-6-[2-(3-hydroxypropylamino)pyridin-4-yl]-5H-pyrrolo-[2,3-b]pyrazine trifluoroacetate salt (0.018 g, 0.05 mmol) was treated with HCl/diethyl ether (1.0 ml of a 1.0 M solution) to give a solid. The ethereal layer was decanted off and the resulting solid was washed twice with ether. Excess ether was carefully blown off with nitrogen gas and the resulting yellow solid was dried in vacuo to 7-(4-fluorophenyl)-6-[2-(3-hydroxypropylamino)pyridin-4-yl]-5H-pyrrolo[2,3-b]pyrazine hydrochloride salt (0.019 g).

Workup

  1. customto give a solid
  2. customThe ethereal layer was decanted off
  3. washthe resulting solid was washed twice with ether
  4. dry with materialthe resulting yellow solid was dried in vacuo to 7-(4-fluorophenyl)-6-[2-(3-hydroxypropylamino)pyridin-4-yl]-5H-pyrrolo[2,3-b]pyrazine hydrochloride salt (0.019 g)

Sources & evidence

ORD record
ord-70738007bcf947cea29a33bee880fe7c
Source dataset
uspto-grants-2003_10
Patent number
US06630485B2

Reaction notes

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